Bupe and QT changes

Buprenorphine Post
Posts: 35

Postby compchat57 » Fri Feb 19, 2016 8:27 am

One can reach no conclusioins (which I suppose is a conclusion) based on this study of yutes.

Posts: 187

Postby Dave » Fri Feb 19, 2016 8:27 am

This is a very unconvincing report. I doubt we should be doing EKGs on all our bupe patients.

Posts: 198

Postby NoDrugs4u » Fri Feb 19, 2016 8:27 am

Good to know. Curious how many here monitor serial EKG's for QT prolongation? I know that I do not.

Posts: 32

Postby robertsonjon » Fri Feb 19, 2016 8:27 am

For anyone who doesn't want to follow the link or read through a study, here's a paste of a couple lines from it:

Conclusions: In this randomized trial, the mean QTc at baseline, before randomization, was higher in BUP than in DETOX patients. Minimal changes in the QTc were seen at 4 and 12 weeks in a few patients in both groups. There was no evidence that buprenorphine-naloxone alone increased the QTc to a level that increased the risk for TdP.

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