P450 metabolism

Buprenorphine Post
sdaviss
Posts: 49

Postby sdaviss » Fri Apr 02, 2004 5:49 am

Sounds like the right reasoning. What a neat drug.
=Steve

mgh63
Posts: 29

Postby mgh63 » Fri Apr 02, 2004 5:49 am

I like your logic wgrass.

wgrass
Posts: 58

Postby wgrass » Fri Apr 02, 2004 5:49 am

Blood levels might be higher and for longer, but if the receptors are saturated with the partial agonist, would not the ceiling remain the ceiling. Elimination enzyme inhibition would then be the same as intentional overdose -- ineffective at securing any increased agonist effect. N'est pas?

sdaviss
Posts: 49

Postby sdaviss » Fri Apr 02, 2004 5:49 am

I think it would be similar to taking a higher dose of it, in that blood levels would be higher.

philobrian
Posts: 106

Postby philobrian » Fri Apr 02, 2004 5:49 am

Steve,
would you expect a different ceiling effect for buprenorphine if "boosted" by enzyme inhibition?
Brian






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