I had the same issue here last month. I corresponded with an addiction specialist who explained that it is possible (but clearly not common) to absorb some naloxone and get a positive for naloxone metabolites via appropriate dosing and routes with buprenorphine/naloxone. However, remember that noroxymorphone is an oxymorphone metabolite as well so our patients could also have had some Opana in the recent past too.
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